Principle of bottle selection for the packaging of pharmaceutical tablets in plastic bottles

In the 1980 s, with the continuous production line introduced from abroad advanced medical plastic, in order to "plastic" generation "bo" prologue began to open, from now on the large capacity of glass bottles, brown gradually withdraw from pharmaceutical tablet packing in this area, instead of medicinal plastic bottles, it mainly nontoxic polymer such as PE, PP, PC, PET, as the main raw material, adopts advanced plastic forming technology and equipment production of medicinal plastic bottles, main holding all kinds of oral tablet, capsule, capsule dosage forms such as solid and liquid preparation of drugs.

The biggest characteristic of plastic bottles for pharmaceutical use is their light weight, non-breakable, clean and beautiful appearance.

And some of its technical indicators and a large number of data show that its chemical resistance, resistance to steam permeability sealing performance is good, it can be completely on the drug in the effective period of safety shielding protection.

In the use of materials on the varieties of bottle bottle with high density polyethylene (HDPE), polypropylene (PP), polycarbonate (PC), polyester (PET), in the early 1990 s, foreign developed blow molding bottles of new materials polyethylene naphthalate formic acid ethyl ester (PEN) plastic bottle, its property better than PET, its high strength, heat resistant performance is good, resistance to ultraviolet radiation, on carbon dioxide gas and oxygen barrier property is good, good chemical resistance, use more widely than PET, PEN material is a new kind of polyester resin at home and abroad in recent years, the positive development, it also has a great drug plastic packaging materials.

-- Principle of bottle selection

Due to the numerous sizes of plastic bottles for medicinal use, some are colorless and some are transparent, with various colors, shapes and categories.

Facing the splendid plastic bottle market, as a pharmaceutical manufacturer, the following principles should be followed when selecting plastic bottles:

1. Choose the main raw materials and additives for plastic bottles.

Solid with plastic product standards, regulations applicable respectively the main raw material, and must conform to the requirements of the non-toxic, no smell, etc, because of the Lord and have a variety of raw materials, which requires comprehensive performance of materials may be chosen, general tablet chooses high density polyethylene, polypropylene bottles, such as need transparency can choose PET bottles, such as drug be blocking performance is higher, and the light resistance, opaque, choose brown, PET bottles better blocking performance for the PEN.

Liquid dosage forms of drugs are usually made of polypropylene bottles or polyester bottles.

Sealing and water vapor permeability of bottle and cap.

Sealability and water vapor permeability are two important technical indexes of plastic bottles for medicinal use.

Iii. Quality standards for plastic bottles.

The quality of products can be analyzed and judged from the product quality standard of the factory.

Pharmaceutical plastic bottle enterprises should formulate enterprise standards stricter than national and industrial standards.

Iv. Quality assurance system.

Auditing suppliers has become an indispensable part of plastic bottle purchase.

Through auditing, the software and hardware facilities, technical equipment and quality level of the production plant can be comprehensively and correctly evaluated.

The stability and compatibility of plastic bottles.

New plastic bottles (or new materials, new processes) should be tested to determine their stability and compatibility with drugs.

The permeation, dissolution, adsorption, chemical reaction and denaturation between drugs and plastic bottles must be determined by scientific testing.