Production process and raw material selection of plastic bottles for pharmaceutical use

1. Production technology

(1) to "force" Extrusion Blow - Blow moulding, also known as hollow Extrusion Blow molding.

The extruder extrudes the hollow tube continuously, cutting it into small sections with scissors (manual) or cutting device (automatic) and then moving it into the extrusion die to make the mold.

Advantages: simple equipment, small investment, low cost price.

Faults: uneven bottle mouth, poor seal.

LDPE is usually used as the raw material, and the permeability resistance is much lower than HDPE/PP, and the charging quality storage period is short.

(2) Two steps "note -" Two steps injection, Blow moulding.

"Injection and blow molding" are carried out by two separate machines, commonly known as the "two-step method".

Step 1: The blank tube is injected by an ordinary injection molding machine. The bottle head part (bottle mouth and thread) of the blank tube has been formed.

Step 2: Manually place the tube blank on a honeycomb heater or an automatic circulating heating conveyor belt to heat and adjust the temperature, and then move to the bottle blower to make the tube blank by blowing it with compressed air.

Advantages: simple equipment, less investment.

The bottle mouth is smooth and sealed well.

The variety development is fast, the mold expense is lower, the cost price is medium, low.

Disadvantages: The injection tube billet and blow molding are carried out step by step, easy to transmit pollution, difficult to ensure bacteria detection, poor product identity, not suitable for mass production.

(3) the one-step "note -" One step injection - Blow moulding.

"Injection, blow molding" is done on the same machine.

According to different types of machines are divided into three stations and two stations "injection - blowing".

The three work stations of the "injection-blow" bottle making machine are equilateral triangle with an Angle of 120°. The first work station is the injection molding work station, the second work station is the blow molding work station, and the third work station is the debottling work station.

The three stations can run at the same time, with high production efficiency and short cycle. Moreover, they can be connected with the conveyor belt for automatic counting and packaging, so as to truly realize "no contact" with hands during the whole production process of plastic bottles for medicinal use, ensuring the hygiene and cleanliness of products.

Two stations "injection-blow" plastic machine two stations can be arranged up, down or in front of;

The first station is the injection molding station, and the second is the blow molding station.

Due to the lack of a special bottle and cooling station, it is difficult to achieve automatic counting packaging (generally manual counting in bulk).

In addition, the production cycle is long, and the production efficiency is lower than three stations.

Advantages: high degree of automation, high production capacity.

High flatness, excellent sealing.

HDPE/PP raw material is selected, the bottle wall is uniform, the anti-permeability is excellent, the charging and storage period is long.

At present, domestic standardized pharmaceutical package enterprises basically adopt one-step "injection and blowing" process equipment, in which "three-station" structure is the main structure.

Disadvantages: large equipment investment, complex mold, high system configuration requirements.

Not suitable for small varieties, small batch production.

But mass production can obtain high quality, low cost and good economic benefits.